Orthomolecular Nutrition & Wellness Center is providing next-generation options for wound care and regenerative treatments.

Please call the clinic to learn more about our Whartons Jelly derived cellular regenerative product.

Clinical Rationale for the use of Wharton’s Jelly-Derived MSCs Wharton’s Jelly Derived Mesenchymal Stem Cells (WJ-MSCs) are a novel cellular repair matrix derived from the Wharton’s Jelly of the umbilical cord. Wharton’s Jelly is a matrix of embryonic connective tissue that is found between the amnion and the umbilical vessels.

Wharton’s Jelly is robust in hyaluronic acid and growth factors and, in comparison to amniotic tissue, contains up to 50 times more growth factors. Acellular Wharton Jelly matrix products (WJUCT) have profound regenerative properties. WJ-MSCs are unique in that they retain a combination of most of their embryonic stem cell (ESC) and mesenchymal stem cell (MSC) markers in primary culture and early passages, thus retaining their multipotent stem cell characteristics. WJ-MSCs contain both human embryonic stem cell (hESC) and human mesenchymal stem cell markers which appear to have many important advantages: they are widely multipotent, are not tumorigenic, and are not immunogenetic. Contrary to what has been observed from other sources of adult MSCs, WJ-MSCs share several of the properties unique to fetal-derived MSCs; they have a greater expansion potential in vitro than other adult MSCs and they express HLA-Class I surface markers but do not express HLAClass II markers. In addition to sharing common surface markers with bone marrow MSCs, WJMSCs also express low levels of transcription factors found in mouse and human embryonic stem cells. These factors play a central role in the regulation of pluripotency and self-renewal that include the POU (Pit/Oct/Unc) domain-containing protein Oct-4, Sox-2 and Nanog.

Indeed, it has been shown that WJ-MSCs are immune suppressive in mixed lymphocytes assays by inhibiting Tcell proliferation. This anti-inflammatory property is a desirable MSC behavior for use in cell Figure 1 therapy. The combination of the Wharton’s Jelly extracellular matrix tissue (WJ-UCT) as well as viable mesenchymal stem cells (WJ-MSCs) coordinates the tissue repair process, regenerative growth factors, and anti-inflammatory cytokines. WJ-MSC and other placenta derived MSC products have the advantage of a higher concentration of MSCs and better immunomodulatory properties compared to concentrated autologous bone marrow aspiration or fat derived stem cells where the cell count typically decreases with the donor’s age (Figure 2) and state of health. Of note, stem cells derived from umbilical cord tissue, particularly those derived from Wharton’s Jelly, have better immunomodulatory properties than with bone marrow or fat derived stem cells.

WJ-MSC products contain up to 80% MSC concentration unlike umbilical cord blood which contains 3-5% MSC concentrations. The higher concentration of mesenchymal stem cells found in Wharton’s Jelly as well as their unique primordial characteristics make WJ-MSC an ideal choice for cellular regenerative therapy. WJ-MSC is obtained from carefully screened, healthy donors at the time of scheduled cesarean section and causes no harm to mother or her newborn child making it easily accessible and without the many limitations or ethical issues of embryonic stem cells and their derivatives.

Supportive Studies/Abstracts: 1: Mobasheri A, Csaki C, Clutterbuck AL, Rahmanzadeh M, Shakibaei M. Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy. Histol Histopathol. 2009 Mar;24(3):347-66. doi: 10.14670/HH-24.347. Review. PubMed PMID: 19130405. 2: Qi Y, Feng G, Yan W. Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis. Mol Biol Rep. 2012 ay;39(5):5683- 9. doi: 10.1007/s11033-011-1376-z. Epub 2011 Dec 20. Review. PubMed PMID: 22183306. 3: Nöth U, Steinert AF, Tuan RS. Technology insight: adult mesenchymal stem cells for osteoarthritis therapy. Nat Clin Pract Rheumatol. 2008 Jul;4(7):371-80. doi: 10.1038/ncprheum0816. Epub 2008 May 13. Review. PubMed PMID: 18477997. Figure 2 4: Shalini Vellasamy, Pratheep Sandrasaigaran, Sharmili Vidyadaran, Elizabeth George, and Rajesh Ramasamy. Isolation and characterisation of mensenchymal stem cells derived from human placenta tissue. World J Stem Cells. 2012 Jun 26; 4(6): 53–61. Published online 2012 Jun 26. doi: 10.4252/wjsc. v4.i6.53 PMCID: PMC3443712 5: Barlow S, Brooke G, Chatterjee K, Price G, Pelekanos R, Rossetti T, Doody M, Venter D, Pain S, Gilshenan K, Atkinson K. Comparison of human placenta- and bone marrow-derived multipotent mesenchymal stem cells. Stem Cells Dev. 2008 Dec;17(6):1095-107. doi: 10.1089/scd.2007.0154. PubMed PMID: 19006451. 6: Fong CY, Chak LL, Biswas A, Tan JH, Gauthaman K, Chan WK, Bongso A. Human Wharton's jelly stem cells have unique transcriptome profiles compared to human embryonic stem cells and other mesenchymal stem cells. Stem Cell Rev. 2011 Mar;7(1):1-16. doi: 10.1007/s12015-010-9166-x. PubMed PMID: 20602182. 7: Jo CH, Lee YG, Shin WH, Kim H, Chai JW, Jeong EC, Kim JE, Shim H, Shin JS, Shin IS, Ra JC, Oh S, Yoon KS. Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial. Stem Cells. 2014 May;32(5):1254-66. doi: 10.1002/stem.1634. Erratum in: Stem Cells. 2017 Jun;35(6):1651-1652. PubMed PMID: 24449146.



Stem cell therapies have enormous promise, but the science in each use is still in the developmental stage. Professional judgment and expertise is needed in using stem cells for any therapeutic use, and we urge anyone embarking on the use of stem cell therapies to consult the national health data bases to evaluate current information from clinical trials. The FDA websites on human tissue should also be consulted to get its current evaluation of any therapy. Stem cells, like other medical products that are intended to treat, cure or prevent disease, generally require FDA approval before they can be marketed. FDA has not approved any stem cell-based products for use, other than cord blood-derived hematopoietic progenitor cells (blood forming stem cells) for certain indications.

[Designated for Human Homologous Allograft use, under FDA under 21 CFR Part 1271 and Section 361 of the Public Health Service Act. Healthy live donors, provide the placental tissue at the time of scheduled Caesarian Section. Donors are pre-screened through a intensive and complete medical review and pre-natal evaluation. The placental tissue is processed, cleansed, and packaged at a AATB accredited tissue bank.]

What is PEMF Pulsed Electromagnetic Field Therapy?

All energy is electromagnetic in nature, and nothing happens in the body without an electromagnetic exchange between cells. We are all familiar with the electrocardiogram (EKG) and electroencephalograph (EEG) tests, which measure the electromagnetic activity of the heart and brain, respectively. When electromagnetic activity ceases, life ceases. Electromagnetic energy controls our chemistry. Disruption of this energy in cells causes impaired cell metabolism, and if our cells are not healthy, our body is not healthy, in whole or in part.

PEMF benefits:

  • reducing muscle tension
  • improving tissue healing
  • reducing pain
  • increasing energy
  • improving clotting factors
  • slowing the development of arthritis
  • stimulating the immune system
  • helping the body to detoxify
  • improving the uptake of nutrients
  • reducing blood pressure
  • helping nerve function
  • helping liver function
  • balancing the acupuncture meridians
  • improving sleep
  • making soft tissue more flexible
  • reducing arthritic changes

The PEMF device signal delivers these results in the following improvements:

  • 28% increase in vasomotion
  • 29% increase in micro-circulatory blood perfusion
  • 31% increase in venous return
  • 29% increase in oxygen utilization

***Bemer is unlike any other PEMF device in the market. While PEMF devices create only 300 stimulations per second, the Bemer produces 1200 stimulations per second. And that is why the Bemer signal gets such amazing results and is so superior to any other product.

To schedule a FREE demonstration and session call 727-518-9808 Today!

At Orthomolecular Nutrition and Wellness Center, our mission is to incorporate the science of healing which addresses the whole person.

In practice, this means that every person is seen as a unique individual. For that reason, we cater each person's treatment to their specific needs (rather than using a "one size fits all" style of therapy).

Orthomolecular medicine is all about providing the body with the correct amount of naturally occurring substances; such as vitamins, minerals, amino acids and herbs. Therefore, we only use a natural and holistic approach to healthcare, allowing us to help our patients balance their body and bring themselves to optimal health, vitality, performance, as well as increased longevity.

The GI Effects Comprehensive Stool Profile is the stool test of choice for optimizing clinical value in managing gut health and has been enhanced to now offer:

  • Further insight into gut flora by identifying 24 Commensal Bacteria targets using PCR technology
  • Identification of parasites using O&P technology
  • Biomarkers indicating levels of digestive and absorptive functions, as well as potential issues with gut inflammation and immunology

Why use targeted stool testing?

Gastrointestinal function is critical for good health. The intestinal tract contains significant amounts of bacteria which, when imbalanced, scientific literature has associated with a wide variety of common illnesses including, but not limited to:

  • Irritable Bowel Syndrome (IBS)
  • Inflammatory Bowel Disease (IBD)
  • Autoimmune Disorders
  • Diabetes
  • Cardiovascular Disease

Additionally, balancing gut microbiota is key for improving core gastrointestinal functions, such as digestion and absorption of nutrients, as well as metabolic functions. Poor digestion and malabsorption may impact immune function, optimum nutritional status, and mood.

Why is the GI Effects Comprehensive Stool Profile the best stool test for gastrointestinal diagnostics?

By evaluating targeted biomarkers, the GI Effects Comprehensive Stool Profile can reveal hidden conditions that other stool tests may overlook. Now with the use of Calprotectin, the GI Effects Comprehensive Stool Profile is a simple, yet more superior stool test that has the ability to differentiate Irritable Bowel Syndrome from Inflammatory Bowel Disease. Other benefits include:
  • More Actionable Results GI Effects Stool Profiles utilize the best technologies available to manage gut health, including enhanced molecular (PCR) technical performance, an expanded number of commensal targets, detection of parasites, and premier inflammatory and metabolic biomarkers – all designed to increase the prevalence of clinically actionable results.
  • Enhanced Clinical Utility Our value-added report provides Interpretation At-a-Glance that provides immediate treatment insight via key biomarkers for Infection, Inflammation, Insufficiency, and Imbalances by using graphics designed to place immediate focus on the big picture. The Interpretation At-a-Glance also summarizes commensal bacterial patterns into global markers of gut health in a Diversity Association graphic. As well, our Relative Abundance graphic provides a comparison of the patient's microbial abundance to a healthy cohort of patients.
  • Option of 1-Day or 3-Day Specimen Collection Our GI Effects Stool Profiles allow the choice of either one- or three-day collection based on your clinical concerns and the needs of your patient. Genova uses stool ova and parasites (O&P) testing to detect parasites and their eggs within the gastrointestinal tract. While literature suggests that >90% of enteric parasitic infections may be detected in a sample from a single (or one day) stool collection, increased sensitivity results from the collection of additional specimens on separate days - and collection of multiple samples is the clinical gold standard for assessing parasitic infection in patients for whom there is a high clinical index of suspicion.
  • NEW Biomarkers & Add-ons The GI Effects Comprehensive Stool Profile now includes biomarkers such as Calprotectin and Pancreatic Elastase 1, as well as premier inflammatory and metabolic biomarkers such as EPX and Beta-glucaronidase. It also offers five additional add-ons – including EIA assessment of pathogenicbacteria – for greater utility: HpSA - H.pylori, Campylobacterspp, Clostridium difficile, Shiga toxin E. coli and Fecal Lactoferrin.

The GI Panel Analyte List:

  • Acetate %
  • Akkermansia muciniphila
  • Anaerotruncus colihominis
  • Bacteriology
  • Bacteroides vulgatus
  • Bacteroides-Prevotella group
  • Barnesiella spp.
  • Beta- glucuronidase
  • Bifidobacterium longum
  • Bifidobacterium spp.
  • Butyrivibrio crossotus
  • Calprotectin
  • Cholesterol
  • Clostridium spp.
  • Collinsella aerofaciens
  • Color
  • Consistency
  • Coprococcus eutactus
  • Desulfovibrio piger
  • Eosinophil Protein X (EPX)
  • Escherichia coli
  • Faecalibacterium prausnitzii
  • Fecal Fat (Total)
  • Fecal Occult Blood
  • Fecal sIgA
  • Firmicutes/Bacteroidetes (F/B Ratio)
  • Fusobacterium spp.
  • Lactobacillus spp.
  • Long Chain Fatty Acids
  • Methanobrevibacter smithii
  • Mic Sensitivities, Yeast or Bacteria
  • Microscopic Exam Results
  • Mycology (Yeast/Fungi)
  • Odoribacter spp.
  • Other Biomarkers
  • Oxalobacter formigenes
  • Pancreatic Elastase 1
  • Parasitology
  • Parasitology EIA Tests
  • Phospholipids
  • Prevotella spp.
  • Products of Protein Breakdown (Total) (Valerate+Isobutyrate+Isovalerate)
  • Propionate %.
  • Pseudoflavonifractor spp.
  • Roseburia spp.
  • Ruminococcus spp.
  • SCFA (Total) (Acetate, n-Butyrate, Propionate)
  • Triglycerides
  • Veillonella spp.
  • n-Butyrate %
  • n-Butyrate Concentration
Orthomolecular Nutrition & Wellness Centers first step is to assess the patients’ neurotransmitter and adrenal hormone biomarkers with a functional laboratory test.

NeuroLab™ from Sanesco provides our patients with 3 primary profiles that measure 6 primary urinary neurotransmitters: Serotonin, GABA, Glutamate, Dopamine, Norepinephrine, and Epinephrine. Salivary adrenal hormones are also measured: 4 timed Cortisols and 2 DHEA. This profile assesses the six neurotransmitters that affect the hypothalamic-pituitary axis (HP) as well as the adrenal hormones cortisol and DHEA. Since the HPA axis initiates an adrenal response, this profile allows the practitioner to assess that response and make therapeutic decisions based on the information. Neurotransmitters are measured from a single urine sample, while cortisol (X4) and DHEA (X2) are measured from four saliva samples, the first taken between 7:00 and 8:00 am and then one every five hours thereafter for the remaining three samples. Orthomolecular Nutrition & Wellness provides a correlation analysis that includes unique clinical decision support and risk management personalized with respect to your patients. Customized functional input is included in each report, as each patient has a unique biochemical make up and variety of lifestyle factors and symptoms. The clinical team is correlating patient lab values to symptoms and severity, medications and dosages, lifestyle factors, medical diagnoses, supplements, and demographics to best analyze these interrelated variables and what this means for you and your patient.

Patient Discovery

When a patient presents one or more symptoms to our practitioner, they are given the appropriate Sanesco test collection kit(s) to establish baseline levels. Each non-invasive urine and/or saliva test provides a convenient, at-home collection method that encourages patient compliance. Urine testing follows an CLIA-approved technology developed by Sanesco’s scientific board . The patient mails the collected sample(s) to Sanesco in a pre-addressed, postage-paid box. Together with the patient’s symptoms, it is logged by Sanesco and forwarded to NeuroLab™ for processing. Test results are sent to Sanesco, whose expert team of multi-disciplinary researchers and clinicians develops a recommended treatment protocol that takes into consideration the patient’s symptoms, the test results and the over 100 self-reported lifestyle, medication, supplementation, medical history factors. A copy of the test results is then forwarded to the practitioner together with Sanesco’s individualized interpretation and educational comments. Whenever requested, Sanesco’s expert team is also available to further interpret test results and assist the practitioner in selecting a viable therapeutic approach. A key advantage of Sanesco’s functional assessment protocol is testing frequency. After an initial baseline is established, it is very important to regularly retest a patient’s neuronal and hormonal responses to measure changes that occur over time. Once therapy is initiated,the patient’s levels begin to shift; retesting allows the restoration of a patient’s health, a period that may last from three to nine months, depending on the individual and the severity of their symptoms. When a patient’s symptoms are relieved and long-term health has been restored, annual or semi-annual testing is conducted to maintain the patient’s state of health and prevent the return of symptoms.

Baseline Laboratory Assessment

Sanesco’s CSM™ process begins with assessment of a patient’s neurotransmitter and adrenal hormone levels with a non invasive lab test. This first step is necessary to begin to fully understand our patient’s neuro-hormonal status. An initial test established a baseline, and helps reveal underlying imbalances that may contribute to the manifestation of symptoms. Unlike traditional test and treat diagnostic models. Our laboratory assessment includes non-invasive serial testing that allows you to monitor changes in neuronal and hormonal responses over time, letting us make adjustments to a patient’s therapeutic protocol to achieve an optimal neuroendocrine balance and effective clinical outcomes.

Retesting for Neuroendocrine Optimization

One of the cornerstones of the CSM™ clinical model is retesting. Monitoring neurotransmitter and hormone levels throughout the rebalancing process is the most effective way of guiding individual therapy. The patient’s current response can be measured against previous results and symptoms, allowing for imbalances to be more adequately addressed. Targeted Nutritional Therapy will be adjusted as results are viewed and compared. With each retest, the patient is moving closer to achieving HPA axis and symptom balance.Example showing the previous and current values are below.

What is a neurotransmitter?

The brain makes chemical messengers calledneurotransmitters. Neurotransmitters are produced and stored in the brain and are released into action when the brain cells are electronically activated. They areresponsible for every thought, mood, pain and pleasure sensation we feel. They controlour energy level, our appetite and the foods we crave. Neurotransmitters even regulatehow well we sleep as well as our sex drive. Psychological stress and physiological changes can cause neurotransmitter deficiencies orimbalances; likewise, the neurotransmitter deficiency or imbalance can causepsychological changes. Neurotransmitters can be easily measured by specialized noninvasivelaboratory testing. Thinking of it this way: it is common to measure thyroid levels before prescribingmedication and to test a diabetic’s blood sugar before adjusting the dose of insulin.Therefore, before treating an individual with neurotransmitter imbalances, it is importantto identify their specific levels in order to recommend the best therapeutic support. Neurotransmitters and hormones commonly measured are serotonin, dopamine, GABA,nor epinephrine, epinephrine, glutamate, cortisol, DHEA and thyroid. A deficiency ofany particular neurotransmitter not only affects neuronal function but also endocrinefunction anywhere in the body. Our endocrine system is considered primary and critical to all metabolic function.Glands such as the thyroid, the adrenals, the ovaries and the testes all take direction fromthe brain. There are many conditions that negatively impact hormone levels, and whenone hormone is imbalanced, there is a tendency for many other hormones to follow suit. Correction of imbalanced hormones is important but not always sufficient. Correction ofimbalanced neurotransmitters, on the other hand, is imperative if clinical progress is to bemade. Determining which neurotransmitters are low and which are high should precedeclinical intervention. For instance, combining poor diet with a stressful life-style is a recipe forneurotransmitter imbalances. The types of food we crave (starches, chocolate or sweets)and the time of day we crave them (late afternoon or evening) may characterize specific neurotransmitter deficiencies. In fact, serotonin depletion is one of the most commonneurotransmitter imbalances in our culture.

Common symptoms/conditions ofserotonin/dopamine imbalances include:

  • Anxiety and panic attacks
  • Insomnia
  • Fatigue
  • Strong craving for sweets
  • Depression
  • Difficulty concentrating
  • Headaches (including migraines)
  • Low motivation
  • Chronic pain
  • ADD
  • Irritability and anger disorders
  • PMS
  • Seasonal affective disorders
  • Addictions
  • Decreased sex drive

What causes neurotransmitter deficiencies?

Weight Loss / Dieting

Dieting is the most common cause of self-induced neurotransmitter deficiencies. Protein deficientdiets may not supply adequate tryptophan, which is necessary for serotoninproduction. Carbohydrate is necessary to deliver tryptophan to the brain for serotoninproduction. High protein/low carbohydrate diets are a two-fold problem – there is notenough insulin and too much amino acid competition, which restricts the basic buildingblocks needed to produce enough neurotransmitters. Studies from major universities, including Harvard, MIT and Oxford, have documentedthat women on diets significantly deplete their serotonin within three weeks of dieting! This induced serotonin deficiency eventually leads to increased cravings, moodiness andpoor motivation, which all contribute to rebound weight gain – the common yetunfortunate consequence of dieting. Diets may also be deficient in B-vitamins and othernecessary nutrients. Folic acid, B6, and magnesium are all required in the process ofserotonin production. Therefore, it is so important to see a health care professional foryour weight loss program where you have the opportunity for neurotransmitter supportthat can help ensure successful weight loss with a healthy program specifically designedfor you.

Certain Medications

Long term use of diet pills, stimulants, pain pills, narcotics and recreational drugs candeplete neurotransmitter stores. Diet pills (like phen-fen , phenteramine) use up largeamounts of dopamine and serotonin, which can result in “rebound” appetite controlproblems, low energy, unstable moods and a sluggish metabolism.

Prolonged Emotional or Physical Stress

The human body is designed to handle sudden, acute or short bouts of stress. Prolongedchronic stress takes its toll on the “fight or flight” stress hormones and neurotransmitters.Eventually, these become depleted and coping becomes more difficult.


Sixty percent of all adults over the age of 40 have some degree of neurotransmitterdeficiencies. Aging brain cells make smalleramounts of neurotransmitters. Also, as weget older, the body does not respond as well to them.

Abnormal Sleep

Stressors of all sorts can become chronic and cause adrenal fatigue. Manyneurotransmitters are responsible for proper sleep, especially serotonin and are productduring REM sleep around 2 to 3 am when serotonin converts to melatonin, the sleephormone. When serotonin levels are low melatonin level will also be low. Disruptedsleep occurs and fewer neurotransmitters are produced causing a sleepless night.

Heavy Metal Toxicity

Mercury, lead, aluminum, cadmium and arsenic are major neurotoxins. Chemicalpesticides, fertilizers, certain cleaning agents, industrial solvents and recreational drugscause damage to the brain cells and decrease neurotransmitter production.


Any condition ending in “it is,’ such as sinusitis, gastritis or arthritis is an inflammatorycondition. Inflammation interferes with the conversion of tryptophan to 5-HTP which isused in the body’s production of serotonin.

Hormonal Imbalance

If hormones are deficient or are off balance, neurotransmitters do not function well.Premenstrual Syndrome (PMS) is a classic example of how low serotonin levels can shifteach month. Mood, appetite and sleep can be severely disrupted one or two weeks beforethe menstrual cycle. Another neurotransmitter imbalance occurs during menopause whendramatic changes in mood, energy, sleep, weight and sexual desire occur.

Genetic Predisposition

Some people are born with a limited ability to make adequate amounts ofneurotransmitters. They exhibit deficiency symptoms as children or young adults andoften have relatives who suffer from significant mental illnesses. As they age, affectedindividuals experience even more profound symptoms and debilitation. To learn more about the lab we use for testing go to Sanesco’s website at: http://www.sanescohealth.com/neurolab/ Our practitioners will go over the extensive test results that we receive from the lab to provide a protocol to help balance and optimize your neurotransmitters.