MOLECULAR HYDROGEN THERAPY

ANTI-CANCER

Malignant oxygen free radicals are the fundamental factors causing pathological changes, cancer, and accelerated aging. Smoking, stress, and lack of sleep can all produce peroxygen-free radicals. There are numerous ongoing and completed studies validating the effects on how ingestion of molecular hydrogen helps your body fight diseases such as cancer by eliminating malignant super oxidative oxygen free radicals, as well as other dangerous and damaging free radicals. Easing the burdens of cellular decay caused by aging and everyday life is the function of hydrogen molecules in your body.

BRAIN ENHANCER

Molecular Hydrogen will strengthen the process of nerve conduction, promote the differentiation of neural stem cells, and improve the oxygen content of red blood cells and blood circulation. It also penetrates the blood-brain barrier, providing your mind with an abundance of hydration and fresh energy. 

Fluids flow throughout your whole body more freely, which provides your brain with more energy and all the fluids it needs, enhancing mental performance. Easing the movement of the body’s gas increases the entire vitality of the human body and significantly promotes your memory and thinking while improving your attention and ability to store information.

POWERFUL ANTIOXIDANT

Molecular Hydrogen is the smallest molecule and strongest antioxidant in the world. It easily penetrates all cells in the body as well as the blood-brain barrier. H2 actively seeks out and neutralizes more super oxidative malignant oxygen free radicals than any other antioxidants. 

Reactive oxygen attacks DNA in normal cells, which causes more than 70 fatal chronic diseases such as cancer, gene mutation, vascular disease, dementia, Parkinson’s disease, heart attack, stroke, and diabetes. This is why keeping your body super hydrated at all times allows you to naturalize more bad free radicals while providing energy, which helps your body stay strong and improves your overall ability to fight off disease.

ENERGY

Molecular Hydrogen boosts energy by enhancing nerve conduction and improving the oxygen content of red blood cells, leading to improved blood circulation. Its ability to penetrate the blood-brain barrier provides the brain with fresh energy. Molecular Hydrogen promotes the differentiation of neural stem cells, supporting the brain’s overall health and vitality. It works to optimize energy levels and provide a rejuvenating effect for both the mind and body.

SKIN CARE/WRINKLE REDUCER

The basis of all skin creams is that they add and lock hydration into your skin. By super hydrating your body from within, the slow release of molecular hydrogen improves skin elasticity, smoothness, and color & slows the wrinkling effects of aging. Facial wrinkles can easily be reduced and eliminated with an improvement in color by resisting the oxidation of mitochondria. 

H2 molecular hydrogen tablets slow release of hydrogen from within keeps your skin continuously supple, smooth, and soft. Rather than just locking moisture into your skin like most face creams, we can supply our bodies with constant super hydration, keeping skin fully hydrated at all times from within. Fighting exciting wrinkles by soothing skin from within and helping to slow the appearance of new wrinkles as we age.

LIBIDO

Slow-release Molecular Hydrogen H2 Life Extension tablets from our wellness center in Largo, FL, give your body more than just hydration but a dramatic increase in your energy and circulation. Oxygen has eight electrons compared to hydrogen, which has only one electron, but it has the property of imparting electrons to other substances, so our body gains energy through hydrogen. 

The improved circulation provides your libido with increased energy for better performance, potency, and pleasure. H2 also reduces muscle fatigue. When you exert yourself, your lactic acid increases. Lactic acid buildup leads to fatigue, muscle damage, decreased endurance, reduced performance, and poor results. Peer-reviewed research shows that molecular hydrogen decreases lactic acid levels.

ATHLETIC PERFORMANCE

H2 Increases Your Energy by stimulating the release of Adenosine Triphosphate (ATP). ATP is the fuel that powers your cells during physical activity. ATP is especially important for athletes. Peer-reviewed research showed that Diatomic Molecular Hydrogen (H2) increased the efficiency of the mitochondria, producing more ATP in athletes. Supplementing with H2 tablets helps maintain the high ATP production needed during exercise, providing optimal strength, endurance, and recovery. 

Increases in oxygen can produce more free radicals, leading to chain reactions and cell damage. When your respiration increases through exercise, this produces greater amounts of oxidative stress on your body, limiting your athletic performance. Two to five percent of the oxygen inhaled by the body can generate super oxidative malignant free radicals. 

Sweating throughout exercise dehydrates your body, which is why drinking lots of water during exertion is important. The slow release of molecular hydrogen inside your body while you work out provides you with sustained hydration, fights super oxidative malignant free radicals & stimulates the production of ATP which increases your athletic performance.

LONGEVITY

Think about fruit left out to dehydrate vs. fruit protected from dehydration. Your body is the same! Extend the length of enzyme-telomerase, and it’s possible to prolong the lifespan of the human body. Hydrogen and oxygen have the opposite effect on reduction. Reduction means returning to the original state, giving electrons to substances captured by reactive oxygen, and restoring them to their original state. 

Dehydration and oxidation are the biggest causes of aging. By ingesting molecular hydrogen, you super hydrate and anti-oxidize your body. This extends your lifespan by fighting free radical damage. Oxidation is literally the aging process, while molecular hydrogen supplementation prevents or slows the aging process by slowing oxidative damage.

REDUCE INFLAMMATION

H2 Life Extension Molecular Hydrogen Tablets improve pancreatic B cell dormancy and promote glucose metabolism. The joints in your body are lubricated by lipids, H2O, and other fluids. By keeping your body fully hydrated with Molecular Hydrogen, it allows your joints to move more freely, thereby reducing inflammation. By reducing inflammation, you relieve pain and soothe everyday aches and pains.

REFERENCES

“Real World Survey” Of Hydrogen-Controlled Cancer

Chen, J.-B., Kong, X.-F., Lv, Y.-Y., Qin, S.-C., Sun, X.-J., Mu, F., Lu, T.-Y., & Xu, K.-C. (2019). “Real world survey” of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients. Medical Gas Research, 9(3): 115–121.

Molecular Hydrogen: Potential In Mitigating Oxidative-Stress-Induced Radiation Injury. Canadian Journal Of Physiology & Pharmacology

Kura, B., Bagchi, A. K., Singal, P. K., Barancik, M., LeBaron, T. W., Valachova, K., Šoltés, L., & Slezák, J. (2018)., Molecular Hydrogen: Potential In Mitigating Oxidative-Stress-Induced Radiation Injury. Canadian Journal Of Physiology & Pharmacology 97(4).

Effects Of Drinking Hydrogen-Rich Water On The Quality Of Life Of Patients Treated With Radiotherapy For Liver Tumors

Kang, K.-M., Kang, Y.-N., Choi, I.-B., Gu, Y., Kawamura, T., Toyoda, Y., & Nakao, A.  (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1(1): 11.

Possible Clinical Effects Of Molecular Hydrogen (H2) Delivery During Hemodialysis In Chronic Dialysis Patients

Nakayama, M., Itami, N., Suzuki, H., Hamada, H., Osaka, N., Yamamoto, R., Tsunoda, K., Nakano, H., Watanabe, K., Zhu, W.-J., Maruyama, Y., Terawaki, H., Kabayama, S., Nakazawa, R., Miyazaki, M., & Ito, S. (2017). Possible clinical effects of molecular hydrogen (H2) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. PLOS One, 12(9): e0184535.

Protective Effect Of Hydrogen-Rich Water On Liver Function Of Colorectal Cancer Patients Treated With mFOLFOX6 Chemotherapy

Therapeutic Efficacy Of Infused Molecular Hydrogen In Saline On Rheumatoid Arthritis

Ishibashi, T., Sato, B., Shibata, S., Sakai, T., Hara, Y., Naritomi, Y., Koyanagi, S., Hara, H., & Nagao, T. (2014). Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study. International Immunopharmacology, 21(2): 468–73.

Hydrogen-Rich Water Reduces Inflammatory Responses

Sim, M., Kim, C.-S., Shon, W.-J., Lee, Y.-K., Choi, E. Y., & Shin, D.-M. (2020). Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: A randomized, double-blind, controlled trial. Scientific Reports 10, Article 12130.

Effects Of High-Concentration Hydrogen-Rich Water On Body Composition Including Inflammation Biomarkers

LeBaron, T. W., Singh, R.B., Fatima, G., Kartikey, K., Sharma, J. P., Ostojic, S. M., Gvozdjakova, A., Kura, B., Noda, M., Mojto, V., Niaz, M. A., & Slezak, J. (2020). The effects of 24-week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: a randomized controlled trial. Diabetes Metabolic Syndrome and Obesity, 13, 889–896.

Hydrogen-Enriched Water For Mitochondrial & Inflammatory Myopathies

Ito , M., Ibi, T. , Sahashi, K., Ichihara , M.,  Ito , M.,& Ohno, K. (2011). Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Medical Gas Research, 1, 24.

Water Containing A High Concentration Of Molecular Hydrogen Water Reduces Oxidative Stress & Disease activity In Patients With Rheumatoid Arthritis

Ishibashi, T., Sato, B., Rikitake, M., Seo, T., Kurokawa, R., Hara, Y., Naritomi, Y., Hara, H., & Nagao, T. (2012). Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: An open-label pilot study. Medical Gas Research, 2(1): 27.

Effectiveness Of Oral & Topical Hydrogen For Sports-Related Soft Tissue Injuries

Ostojic, S. M., Vukomanovic, B., Calleja-Gonzalez, J., & Hoffman, J. R. (2015). Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgraduate Medicine, 126(5).

Acute Hydrotherapy With Super-Saturated Hydrogen-Rich Water

Dejan, J. & Stajer, V. Case report: acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete 

Hydrotherapy With Hydrogen-Rich Water Compared With RICE Protocol

Javorac, D., Stajer, V., Ratgeber, L., Olah, A., Betlehem, J., Acs, P., Vukomanovic, B., & Ostojic, S. M. (2020). Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial. Research in Sports Medicine, 1–9.

Hydrogen-Rich Water & Oxycodone Hydrochloride Controlled-Release Tablets In The Treatment Of Malignant Neuropathic Pain

Li, D. Yan, M. (2016). Clinical assessment of hydrogen-rich water and oxycodone hydrochloride controlled-release tablets in the treatment of malignant neuropathic pain. Journal of Chinese Physician, 18(9):1329-1331,1335

A Novel Bioactive Haemodialysis System Using Dissolved Dihydrogen (H2)

Nakayama, M., Nakano, H., Hamada, H., Itami, N., Nakazawa, R., & Ito, S. (2010). A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: A clinical trial. Nephrology Dialysis Transplantation, 25(9): 3026–3033.

Hydrogen Vs. Caffeine for Improved Alertness In Sleep-Deprived Humans

Zanini, D., Stajer, V., & Ostojic, S. M. (2020). Hydrogen vs. caffeine for improved alertness in sleep-deprived humans. Neurophysiology 52, 67–72.

Molecular Hydrogen Study On Mild Cognitive Impairment

Nishimaki, K., Asada, T., Ohsawa, I., Nakajima, E., Ikejima, C., Yokota, T., Kamimura, N., & Ohta, S. (2018). Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Current Alzheimer Research., 15(5): 482–492.

H2 Therapy In Parkinson’s Disease

Yoritaka, A., Takanashi, M., Hirayama, M., Nakahara, T., Ohta, S., & Hattori, N.  (2013). Pilot study of H₂ therapy in parkinson’s disease: a randomized double-blind placebo-controlled trial. Movement Disorders, 28(6): 836–9.

Hydrogen Gas Inhalation For Improving Patients With Alzheimer’s Disease

Ono, H., Nishijima, Y., Sakamoto, M., Horikosi, T., Tamaki, M., Oishi, W., Naitoh, Y., Futaki, T., Ishii, S., Suzuki, K., Kurihara H., & Ohta, S. (2018). Pilot Study on Therapeutic Inhalation of Hydrogen Gas for Improving Patients with Alzheimer’s Disease Assessed by Cognitive Subscale Scores and Magnetic Resonance Diffusion Tensor Imaging. International Journal of Alzheimers & Neurological Disorders, 1(1): 004.

Short-Term H2 Inhalation Improves Cognitive Function In Older Women

Korovljev, D., Trivic, T., Stajer, V., Drid, P., Sato, B., & Ostojic, S. M. (2019). Short-term H2 inhalation improves cognitive function in older women: A pilot study. International Journal of Gerontology, 14 (2): 149–150.

Hydrogen Gas Inhalation For Treatment Of Cerebral Infarction

Ono, H., Nishijima, Y., Ohta, S., Sakamoto, M., Kinone, K., Horikosi, T., Tamaki, M., Takeshita, H., Futatuki, T., Ohishi, W., Ishiguro, T., Okamoto, S., Ihsii, S., & Takanami, H. (2017). Hydrogen gas inhalation treatment in acute cerebral infarction: A randomized controlled clinical study on safety and neuroprotection. Journal of Stroke & Cerebrovascular Diseases, 26(11): 2587–2594.

Molecular Hydrogen (H2) Inhalation In Acute Cerebral Ischemia Patients

Ono, H., Nishijima, Y., Adachi, N., Sakamoto, M., Kudo, Y., Kaneko, K., Nakao, A., & Imaoka, T. (2012). A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level. Medical Gas Research, 9(21).

Improved Brain Stem Treatment With Hydroxyl Radical Scavengers, Edaravone & Hydrogen

Ono, H., Nishijima, Y., Adachi, N., Tachibana, S., Chitoku, S., Mukaihara, S., Sakamoto, M., Kudo, Y., Nakazawa, J., Kanedo, K., & Nawashiro, H. (2011). Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. a non-controlled study. Medical Gas Research, 1(12).

Safety Of Intravenous Administration Of Hydrogen-Enriched Fluid In Patients

Nagatani, K., Nawashiro, H., Takeuchi, S., Tomura, S., Otani, N., Osada, H., Wada, K., Katch, H., Tsuzuki, N., & Mori, K. (2013). Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Medical Gas Research, 3: 13. 

Efficacy Of Hydrogen Water Treatment Of Neonatal Hypoxic-Ischemic Encephalopathy (HIE)

Yang, L, Li, D., & Chen, S. (2016). Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy. Open Medicine, 11(1): 399–406.

Inhalation Of Hydrogen Gas Elevates Urinary 8-hydroxy-2′-deoxyguanine In Parkinson’s Disease

Hirayama, M., Ito, M., Minato, T., Yoritaka, A., LeBaron, T. W., & Ohno, K. (2018). Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease. Medical Gas Research, 8(4): 144–149.

Treatment With Hydrogen-Producing Blend After A Mild Traumatic Brain Injury

Javorac, D., Stajer, V., & Ostojic, S. M. (2019). Case Report: Buccal Administration of Hydrogen-Producing Blend After a Mild Traumatic Brain Injury in a Professional Athlete. [version 1; peer review: 2].F1000 Research, 8: 1024.

Use Of Hydrogen Water & Photobiomodulation On Parkinson Disease

Hong, C.-T., Hu, C. J., Lin, H.-Y., & Wu, D. (2021). Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study. Medicine (Baltimore), 100(4): e24191.

Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion

Takeuchi, S., Kumagai, K., Toyooka, T., Otani, N., Wada, K., & Mori, K. (2021). Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage. Stroke, 52(1), 20–27. 

Hydrogen Inhalation For Parkinson’s Disease

Yoritaka, A., Kobayashi, Y., Hayashi, T., Saiki S., Hattori, N. (2021). Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study. Neurological Sciences

H2-Infused Beverage As A Neuroprotective Agent For TBIs & Concussions

LeBaron, W. T., Kharman, J., McCullough, L. Michael. (2021). An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions. Journal of Integrative Neuroscience, 20(3).

Hydrogen-Rich Water Bathing On Muscular Damage & Soreness With High-Intensity Exercise

Todorovic, N. Javorac, D., Stajer, V., & Ostojic, S. M. (2020). The effects of supersaturated hydrogen-rich water bathing on biomarkers of muscular damage and soreness perception in young men subjected to high-intensity eccentric exercise. Journal of Sports Medicine.

Molecular Hydrogen Affected Post-Exercise Recovery

Drid, P., Stojanovic, M. D.M., Trivic, T., & Ostojic, S. M. (2016). Molecular hydrogen affected post-exercise recovery in judo athletes. Medicine & Science in Sports & Exercise, 48(5S): 1071

Effects Of Hydrogen-Rich Water On Antioxidant Capacity Of Athletes

Minghao, et al. (2017). Effects of hydrogen-rich water on antioxidant capacity in female judo athletes in training. Chin J Sports Med.*

H2 Inhalation Improves Exercise Performance

Javorac, D., Stajer, V., Ratgeber, L., Betlehem, J., & Ostojic, S. M. (2019). Short-term H2 inhalation improves exercise performance in healthy adults. Biology of Sport, 36(4): 333–339. 

Drinking Hydrogen-Rich Water On Resistance Exercise In Athletes

Moradi, B., Saberi, E., Hasani, & A., Saheb, A. M. The role of drinking hydrogen-rich water produced by alkaline stick on resistance exercise in athletes.

Hydrogen-Rich Water Hydrotherapy For Recovery Of Acute Injury

Alex Tarnava, A. (2021). Supersaturated hydrogen-rich water hydrotherapy for recovery of acute injury to the proximal phalanges on the 5th toe: a case report. Journal of Science and Medicine, 3(1)

Drinking Hydrogen Water Enhances Endurance & Relieves Psychometric Fatigue

Mikami, T., Tano, K., Lee, H., Lee, H., Park, J., Ohta, F., LeBaron, T. W., & Ohta, S. (2019). Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Canadian Journal of Physiology and Pharmacology, 97(9): 857–862. 

Consumption Of Hydrogen-Rich Water On The Antioxidant Activity& Gut Flora On Athletes

Sha, J.-B., Zhang, S.-S., Lu, Y.-M., Gong, W.-J., Jiang, X.-P., Wang, J.-J., Qiao, T.-L., Zhang, H.-H., Zhao, M.-Q., Wang, D.-P., Xia, H., Li, Z.-W., Chen, J.-L., Zhang, L., & Zhang, C.-G. (2018). Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China. Medical Gas Research, 8(4): 135–143. 

Molecular Hydrogen Benefits Submaximal Exercise Indices 

LeBaron, T. W., Larson, A. J., Ohta, S., Mikami, T., Barlow, J. Bullock, J., & DeBeliso, M. (2019). Acute supplementation with molecular hydrogen benefits submaximal exercise indices. randomized, double-blinded, placebo-controlled crossover pilot study. Journal of Lifestyle Medicine, 9(1): 36–43. 

Hydrogen-Rich Water Affects Exercise Capacity In Women

Ostojic, S., Korovljev, D., Stajer, V., & Javorac, D. (2018). 28-days hydrogen-rich water supplementation affects exercise capacity in mid-age overweight women. Medicine & Science in Sports & Exercise, 50(5S): 728–729. 

Protective Effect Of Hydrogen Water On Free Radical Injury After High-Intensity Exercise

Sun, Y.-P. & Sun, L. 2017. Selective protective effect of hydrogen water on free radical injury of athletes after high-intensity exercise. Biomedical Research, 28(10).  

Hydrogen-Rich Water Modulates Redox Status Of Strenuous Exercise

Shibayama, Y.; Takeuchi, K., Dobashi, S., & Koyama, K. (2017). Hydrogen-rich water modulates redox status repeated three consecutive days of strenuous exercise. Medicine & Science inMedicine & Science inSports & Exercise, 49(5S): 941.

Effects Of Drinking Hydrogen-Rich Water On Muscle Fatigue

Aokia, K., Nakao, A., Adachi, T., Matsui, Y., & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2, 12.

Hydrogen Rich Water On Prolonged Intermittent Exercise

Da Ponte, A., Giovanelli, N., Nigris, D., & Lazzer, S. (2017). Effects of hydrogen rich water on prolonged intermittent exercise. The Journal of Sports Medicine and Physical Fitness, 58(5): 612–621. 

Molecular Hydrogen Beneficial To Enhance Post-Exercise Recovery

Drid, P., Trivic, T., Casals, C., Trivic, S., Stojanovic, M., & Ostojic, S. M. (2016). Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes? Science & Sports. 

Hydrogen Rich Water Improves Ventilatory, Perceptual & Lactate Responses To Exercise

Botek, M., Krejci, J., McKune, A., & Sládečková, B. (2019). Hydrogen rich water improved ventilatory, perceptual and lactate responses to exercise. International Journal of Sports Medicine.

Hydrogen-Rich Water Improves The Physical Ability Of Athletes

Wu, P. (2020). Hydrogen-rich water improves the physical ability of football players and the anti-fatigue ability of rats, Revista Cientifica, 30(1): 428-435.

Hydrogen Water Ingestion During Endurance Exercise

Ito, H., Kabayma, S., & Goto, K. (2020).Ito, H., Kabayma, S., & Goto, K. (2020).Effects of electrolyzed hydrogen water ingestion during endurance exercise in a heated environment on body fluid balance and exercise performance. Temperature, 7(3): 290–299.

Molecular Hydrogen As An Antioxidant

Alharbi, A. A. D., Ebine, N., Nakae, S., Hojo, T., & Fukuoka, Y. (2020). Application of molecular hydrogen as an antioxidant in responses to ventilatory and ergogenic adjustments during incremental exercise in humans. Nutrients, 13(2): 459

Hydrogen Bathing On Exercise-Induced Oxidative Stress & Delayed-Onset Muscle Soreness.

Kawamura, T., Gando, Y., Takahashi, M., Hara, R., Suzuki, K., & Muraoka, I.  (2016). Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness. Western Pacific Region Index Medicus.

Hydrogen-RichI Inhalation During Post-Exercise Recovery, Oxidative Stress, Muscle Damage, & Exercise Performance

Shibayama, Y., Dobashi, S., Arisawa, T., Fukuoka, T., & Koyama, K. (2020). Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men. Medical Gas Research, 10(4): 155–162.

Hydrogen-Rich Water Suppresses Reduction In Blood Antioxidant Capacity

Dobashi, S., Takeuchi, K., & Koyama, K. (2020). Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males. Medical Gas Research, 10(1): 21–26

Hydrogen-Rich Water On antioxidant activity, DNA Oxidative Injuries & Diabetes-Related Markers

Asada, R., Tazawa, K., Sato, S., & Miwa, N. (2020). Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. Medical Gas Research, 10(3), 114–121.

Hydrogen Rich Water On Antioxidant Status With Potential Metabolic Syndrome

Nakao, A., Toyoda, Y., Sharma , P., Evans , M., & Guthrie, N. (2010). Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome—An open label pilot study. Journal of Clinical Biochemistry and Nutrition, 46(2): 140–149.

Hydrogen-Rich Water Positive Affects Serum Antioxidant Enzymes

Trivic, T., Vojnovic, M., Drid, P., & Ostojic, S. M. (2017). Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: A pilot study. Current Topics in Nutraceutical Research, 15(1).

Hydrogen-Rich Water Reduces Inflammatory Responses

Sim, M., Kim, C.-S., Shon, W.-J., Lee, Y.-K., Choi, E. Y., & Shin, D.-M. (2020). Hydrogen-rich water reduces inflammatory responses an prevents apoptosis of peripheral blood cells in healthy adults: A randomized, double-blind, controlled trial. Scientific Reports, 10(1): 12130.

Effects Of Drinking A Water Product With Antioxidant Activities

Hiraoka, A., Sasaki, S., Yamada, T., Shinohara, A., & Chiba, M. (2006). Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress. Journal of Health Science, 52(6): 817–820.

Molecular Hydrogen As An Antioxidant In Responses To Ventilatory & Ergogenic Adjustments

Alharbi, A. A. D., Ebine, N., Nakae, S., Hojo, T., & Fukuoka, Y. (2021). Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans. Nutrients, 13(2): 459.

Molecular Hydrogen Inhalation Increases Breath Acetone Excretion During Exercise

Hori, A., Kimura, H., Kondo, T., Ichihara, M., Ogata, H., Hotto, N. (2020). Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study. Medical Gas Research, (10)3

Effects Of Pre-Exercise H2 Inhalation On Physical Fatigue & Related Prefrontal Cortex Activation

Hong Y, Dong G, Li Q, Wang V, Liu M, Jiang G, Bao D and Zhou J (2022) Effects of pre-exercise H2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise. Front. Physiol. 13:988028.

Hydrogen-Rich Water Improves Lipid & Glucose Metabolism

Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N.,  Kitawaki, J., Imai, S., Nakano, K., Ohta, M., Adachi, T., Obayashi, H., & Yoshikawa, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3): 137–43.

Hydrogen-Rich Water Decreases Serum LDL-Cholesterol Levels & Improves HDL Function

Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., Yu, Y., Zong, C., Xue, Y., & Qin, S. (2013). Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 54(7): 1884–93

Molecular Hydrogen Affects Body Composition, Metabolic Profiles & Mitochondrial Function

Korovljev, D., Trivic, T., Drid, P., & Ostojic, S. M. (2018). Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Irish Journal of Medical Science, 87 (1): 85–89.

Hydrogen-Rich Water Positively Affects Homa2 Variables In Physically Inactive Population 

Korovljev, D., Javorac, D., Stajer, V., & Ostojic, S. M. (2019). Hydrogen-rich water positively affects homa2 variables in physically inactive population. Abstracts from the 5th International Scientific Conference on Exercise and Quality of Life, 3. BMC Sports Science, Medicine and Rehabilitation, 11 (1): 7.

Consumption Hydrogen-Rich Water Could Improve Vascular Endothelial Function

Sakai , T., Sato ,B., Hara , K., Hara, Y., Naritomi, Y., Koyanagi, S., Hara, H., Nagao, T., & Ishibashi, T. (2014). Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vascular Health and Risk Management, 10, 591–597.

Peripheral Endothelial Function Can Be Improved By Daily Consumption Of Hydrogen-Rich Water

Ishibashi, T., Kawamoto, K., Matsuno, K., Ishihara, G., Baba, T., & Komori, N. (2020). Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial. PLoS One,15(5): e0233484.

Hydrogen-Rich Water Has Potential To Improve Exercise Performance

Ostojic, S. (2011). Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety. Serbian Journal of Sports Sciences, 5(3): 83–89.

Positive Effects Of Hydrogen-Water Bathing In Patients

Zhu, Q., Wu, Y., Li, Y, Chen. Z., Wang, L., Xiong, H., Dai, E., Wu, J., Fan, B., Ping, L., Luo, X. (2018).  Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep 8, 8051.

Hydrogen-Rich Water Represses Wrinkle Formation

Kato, S., Saitoh, Y., Iwai, K., & Miwa, N. (2012). Hydrogen-rich electrolyzed warm water represses wrinkle formation against uva ray together with type-i collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. Journal of Photochemistry and Photobiology, 106, 24–33.

Hydrogen(H2) Treatment For Acute Erythymatous Skin Diseases

Ono, H., Nishijima, Y., Adachi, N., Sakamoto, M., Kudo, Y., Nakazawa, J., Kaneko, K., & Nakao, A. (2012). Hydrogen(H2) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H2 concentration measurement on two volunteers. Medical Gas Research, 2(1): 14.

Improvement Of Psoriasis-Associated Arthritis & Skin Lesions Molecular Hydrogen Treatment

Ishibashi, T., Ichikawa, M., Sato, B., Shibata, S., Hara, Y., Naritomi, Y., Okazaki, K., Nakashima, Y., Iwamoto, Y., Koyanagi, S., Hara, H., & Nagao, T. (2015). Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Molecular Medicine Reports, 12(2): 2757–64.

Hydrogen Water Treatment For Patients With Pressure Ulcers

Li, Q., Kato, S., Matsuoka, D., Tanaka, H., & Miwa, N. (2013). Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Medical Gas Research, 3(1): 20.

Treatment Of Chronic Graft Vs. Host Disease With Hydrogen-Rich Water

Qian, L.-R., & Shen, J.-L. (2016). Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease. Medical Gas Research, 6(3): 177–179.

H(H2O)m Modulates Basal & UV-Induced Gene Expressions In Human Skin

Shin, M. H., Park, R., Nojima, H., Kim, H.-C., Kim, Y. K., & Chung, J. H. (2013). Atomic hydrogen surrounded by water molecules, H(H2O)m, modulates basal and UV-induced gene expressions in human skin in vivo. PLOS One, 8(4): e61696.

Hydrogen Warm Water Bath Cleanses Keratin-Plug-Clogged Hair-Pores

Tanaka, Y., Saitoh, Y., & Miwa, N. (2018). Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Medical Gas Research, 8(1): 12–18.

Effects Of Hydrogen-Rich Water Bath On Visceral Fat & Skin Blotches

Asada, R., Saitoh, Y., & Miwa, N. (2019). Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. Medical Gas Research, 9(2): 68–73.

Antioxidant Activity Of Hydrogen Water Mask

Kwon, H.-J., Han, S.-B., & Park, K.-W. (2020). Antioxidant activity of hydrogen water mask pack composed of gel-type emulsion and hydrogen generation powder. International Journal of Molecular Sciences, 21(24): 9731.

Heat-Retention Effects Of Hydrogen-Rich Water Bath

Kato, S., Takada, Y., & Miwa, N. (2021). Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans. Journal of Thermal Biology, 95: 102805.

Effects Of Topical Hydrogen Purification On Skin Parameters & Acne Vulgaris

Chilicka, K., Rogowska, A., & Szyguła, R. (2021). Effects of topical hydrogen purification on skin parameters and acne vulgaris in adult women. Healthcare, 9(2): 144.

Hydrogen-Rich Water Improves Wrinkles & Blotches

Yoshiharu T. Nobuhiko M.  (2022) Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture, 3(2):161-178.

Hydrogen-Rich Water Physical Performance

Timón, R., Olcina, G., González-Custodio, A., Camacho-Cardenosa, M., Camacho-Cardenosa, A., & Martínez Guardado, I. (2021). Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects. Biology of Sport 38(2): 269–275

Hydrogen-Rich Water Increases Peak Oxygen Uptake

Hori, A., Sobue, S., Kurokawa, R., Hirano, S.-I., Ichihara, M., & Hotta, N. Two-week continuous supplementation of hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study.  Medical Gas Research, 10(4): 163–169.

Hydrogen-Rich Water Positively Affects Muscle Performance

Botek, M., Krejci, J., Mckune, A. J., Valenta, M., & Sládečková, B. (2021). Hydrogen rich water consumption positively affects muscle performance, lactate response, and alleviates delayed onset of muscle soreness after resistance training. Journal of Strength and Conditioning Research,

Hydrogen-Rich Product On Exercise & Cognitive Performance

LeBaron T., Kharman J., McCullough M. (2021). Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive Performance. Journal of Science and Medicine; 3(2):1-15

Hydrogen-Rich Water Ingestion Stimulates Cardiac Autonomic Activity

Botek, M., Sládečková, B., Krejčí, J., Pluháček, F., Najmanová, E. (2021). Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females. Acta Gymnica, 51, Article e2021.009.

Hydrogen-Rich Water Affects Blood Alkalinity

Ostojic, S. M., & Stojanovic, M. D. (2012). Hydrogen-rich water affected blood alkalinity in physically active men. Research in Sports Medicine, 22(1): 49–60.

Serum Alkalinization & Hydrogen-Rich Water In Healthy Men

Ostojic, S. M. (2012). Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clinic Proceedings, 87(5): 501–502.

Hydrogen Gas Inhalation For Post-Cardiac Arrest Syndrome

Tamura, T., Hayashida, K., Sano, M., Suzuki, M., Shibusawa, T., Yoshizawa, J., Kobayashi, Y., Suzuki, T., Ohta, S., Morisaki, H., Fukuda, K., & Hori, S. (2016). Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome – First-in-human pilot study. Circulation Journal, 80(8): 1870–1873.

Hydrogen-Oxygen Inhalation In Midlife/Older Adults With Hypertension

Liu B, Jiang X, Xie Y, Jia X, Zhang J, Xue Y and Qin S (2022) The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial. Front. Pharmacol. 13:1025487. doi: 10.3389/fphar.2022.1025487

Beneficial Biological Effects & The Underlying Mechanisms Of Molecular Hydrogen

Ichihara, M., Sobue, S., Ito, M., Ito, M., Hirayama, M., & Ohno, K. (2015). Beneficial biological effects and the underlying mechanisms of molecular hydrogen — Comprehensive review of 321 original articles.Medical Gas Research, 5: 12.

Evolution Of Molecular Hydrogen Potential Therapy

Dixon, B. J., Tang, J., & Zhang, J. H. (2013). The evolution of molecular hydrogen: A noteworthy potential therapy with clinical significance. Medical Gas Research, 3(1): 10.

Clinical Effects Of Hydrogen Administration

Nicolson, G. L., Ferreira de Mattos, G., Settineri, R., Costa, C., Ellithorpe, R., Rosenblatt, S., La Valle, J., Jimenez, A., & Ohta, S. (2016). Clinical effects of hydrogen administration: From animal and human diseases to exercise medicine.International Journal of Clinical Medicine, 7(1).

Hydrogen Gas Therapy For Emergency & Critical Care Medicine

Sano, M., Suzuki, M., Homma, K., Hayashida, K., Tamura, T., Matsuoka, T., Katsumata, Y., Onuki, S., & Sasaki, J. (2017). Promising novel therapy with hydrogen gas for emergency and critical care medicine. Acute Medicine & Surgery.

Hydrogen Medicine Therapy Treatment For Multiple Organ Disfunction

Yang, M., Zhang, Z., Gao, B., Liu, L., & Hu, T. (2017). Hydrogen medicine therapy: an effective and promising novel treatment for multiple organ dysfunction (MODS) induced by infuenza and other viral infections diseases? SOJ Microbiology & Infectious Diseases, 5(2): 1–6.

Hydrogen-Rich Water On Biomarkers In Older Adults

Zanini, D., Todorovic, N., Korovljev, D., Stajer, V., Ostojic, J., Purac, J., Kojic, D., Vukasinovic, E., Djordjievski, S., Sopic, M., Guzonjic, A., Ninic, A., Erceg, S., Ostojic, S.M. (2021). The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. Experimental Gerontology, 155

Molecular Hydrogen Significantly Reduces Effects Of Oxidative Stress

LeBaron, T. W., Kura, B., Kalocayova, B., Tribulova, N., & Slezák, J. (2019). A new approach for the prevention and treatment of cardiovascular disorders. molecular hydrogen significantly reduces the effects of oxidative stress. Molecules, 24(11): 2076.

Hydrogen Therapy In Cardiovascular & Metabolic Diseases

Zhang, Y., Tan, S., Xu, J., & Wang, T. (2018). Hydrogen therapy in cardiovascular and metabolic diseases: From bench to bedside. Cellular Physiology and Biochemistry, 47, 1–10.

Improvement Of The Fraction Of human Mercaptalbumi On Hemodialysis Treatment

Maeda, K., Yoshizaki, S., Iida, T., Terada, T., Era, S., Sakashita, K., & Arikawa, H. (2016). Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: A prospective observational study. Renal Replacement Therapy, 2, Article 42.

Improvement Employing Molecular Hydrogen (H2)-Enriched Dialysis Solution

Nakayama, M., Itami, N., Suzuki, H., Hamada, H., Yamamoto, R., Tsunoda, K., Osaka, N., Nakano, H., Maruyama, Y., Kabayama, S., Nakazawa, R., Miyazaki, M., & Ito, S. (2018). Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Scientific Reports, 8, Article 254.

Dissolved Hydrogen Treatment For Peritoneal Dialysis Patients

Terawaki, H., Hayashi, Y., Zhu, W.-J., Matsuyama, Y., Terada, T., Kabayama, S., Watanabe, T., Era, S., Sato, B., & Nakayama, M. (2013). Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Medical Gas Research, 3, Article 14.

Hydrogen/Oxygen Inhalation For Non-Alcoholic Fatty Liver Disease

Geru Tao, Guangjie Zhang, Wei Chen,Chao Yang,Yazhuo Xue, Guohua Song, Shucun Qin (2022) A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease.

Hydrogen-Rich Water In Men at Risk Of Peripheral Arterial Disease

Gu, Q., Liu, B., Xue, J., Zhao, M., Zhang, X., Wang, M., Zhang, M., Xue, Y., Qin, S. (2020). Effects of drinking hydrogen-rich water in men at risk of peripheral arterial disease: A randomized placebo-controlled trial. ResearchGate.

Hydrogen Inhalation Positively Effect Cardiometabolic Risk Factors In Seniors

Korovljev, D., Stajer, V., Javorac, D., & Ostojic, S. M. (2018). Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: A preliminary report. European Geriatric Medicine, 9, 729–730.

Hydrogen Gas Production Is Associated With Reduced Interleukin-1β mrna

Tamasawa, A. & Osonoi, T. (2015). Hydrogen gas production is associated with reduced interleukin-1β mrna in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients. European Journal of Pharmacology, 762, 96–101. 

Hydrogen-Rich Water Reduces Liver Fat Accumulation

Korovljev, D. & Ostojic, S. M. (2019). Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: A randomized controlled pilot trial. Clinics and Research in Hepatology and Gastroenterology, 4 (6): 688–693.

Hydrogen Activates ATP-Binding Cassette Transporter

Song, G., Lin, Q.,   Zhao, H., Liu, M., Ye, F., Sun, Y., Yu, Y., Guo, S., Jiao, P., Wu, Y., Ding, G., Xiao, Q., & Qin, S.   (2015). Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients with Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. The Journal of Clinical Endocrinology & Metabolism, The Journal of Clinical Endocrinology & Metabolism, 100 (7): 2724–33.