What is Glutathione?
A small protein composed of three amino acids: Cysteine, Glutamic acid, and Glycine. Glutathione is involved in detoxification—it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. Glutathione is also the most important antioxidant. In preliminary research, dietary glutathione intake from fruit and raw vegetables has been associated with protection against some forms of cancer. Glutathione has also inhibited cancer in animal studies.
Glutathione is the most important molecule your body needs to stay healthy and prevent disease. Here are some of the following conditions that having the proper amounts of glutathione will not only prevent but will help eradicate.
- Alzheimer’s disease
- Asthma (Inhalation of glutathione available)
- Autoimmune Disease
- Chronic fatigue syndrome
- Chronic Infections
- Heart Disease
- Kidney Problems
- Liver Disease
- Lung Disease/COPD (Inhalation of glutathione available)
- Parkinson’s disease
Orthomolecular Nutrition administers our glutathione by inhalation, injection and as a part of our customized IV nutrient therapy.
S-Acetyl Glutathione (Orally)
Acetylglutathione is orally active, unlike plain glutathione, and is stable in the intestine and plasma when absorbed and delivered directly to the cells for natural deacetylation intracellularly. Plain glutathione delivered to the plasma by precursors, liposomal products, or intravenously must be broken down by enzymes to the basic amino acid components for absorption into the cell, and these require more energy expenditure to be reconstructed back to rGSH. It is known that disease states can block the reassimilation of components into rGSH. Therefore, it is a better dietary/ therapeutic decision to provide the orally active and absorbed acetylglutathione, which increases intracellular rGSH directly and naturally without increased energy expenditure and without being compromised from disease states.
Intracellular Energy Production
Mitochondria are the cell’s fuel source and consume more molecular oxygen than other organelles within the cytosol. This creates reactive oxygen species (ROS), which generate more oxidative stress. This is a reason why mitochondria are a main target for GSH to neutralize ROS and reduce oxidative stress. Entry and replenishment of GSH into the mitochondria are a critical step in maintaining intracellular health.
Acetylglutathione provides replenishment of GSH intracellularly directly, without excess energy expenditure. The efficiency of action and ease of dosing make acetylglutathione an excellent choice for the gold standard of GSH replenishment: to reduce oxidative stress and inflammation of disease progression to maintain a healthy lifestyle.
Currently, the use of GSH orally as a therapeutic agent is limited by its unfavorable biochemical and pharmacokinetic properties. GSH has a short life in human plasma (Less than 3 min) and difficulty in crossing cell membranes, so administration of high doses is necessary to reach a therapeutic value.
Acetylglutathione is more lipophilic than plain glutathione, sufficiently so to be taken up intact by cells, and has been shown to rapidly raise intracellular GSH levels.
S-acetylglutathione is able to increase intracellular-SH groups as reported by Vogel et al., is more stable in blood plasma than GSH, and enters the cells directly, where it is converted to reduced glutathione by the abundant cytoplasm thioesterases.